Hailed as a "genuine phenomenon" by The New York Times, Blake worked in trauma centers around the country before his career in comedy. As a way to cope with the stress of his nursing job, Blake started posting original comedy videos aimed at his profession. His lighthearted videos connected with nurses, nursing students, and healthcare workers around the world gaining Nurse Blake 3.5M followers on social media and over 300M views. He now takes his comedy to stages around the world bringing nurses together through his humor and inspiration. Nurse Blake's sold out 2022 PTO Comedy Tour began as a 14 show run and grew to 55 shows due to demand. Nurse Blake will follow that with his massive Shock Advised Comedy Tour which hits 100 cities across North America in 2023.

Blake is also the is the creator of NurseCon at Sea, one of the largest and most popular nursing conferences, and the NurseCon App which provides the free continuing nursing education courses. He previously managed several large programs including The Banned4Life Project, which ended an outdated FDA blood donor policy, and Nurses Support Their Young which promotes healthy work environments. Blake is also the author of the best-selling children's book "I Want To Be A Nurse When I Grow Up" available online and at bookstores everywhere.